As a part of the Gag family, hyaluronic acid combines with aggrecan ( In the proteoglycan family of chondroitin sulfate) that occurs naturally in the body's fluid, tissue, synovial fluid, and articular cartilage. Joint conditions like arthritis cause hyaluronic acid to break down and deteriorate naturally within the joints. Consequently, hyaluronidase is released into the body to attack the natural production of hyaluronic acid. In the therapeutic industry, hyaluronic acid is used for wound dressing, osteoarthritis medication, burn therapy, ophthalmic medicine, stomach ulcer treatments, and skin care treatment. The properties of hyaluronic acid include its ability to lubricate, and high viscoelasticity, which makes them useful for shock absorption, and support of joint composition.

Researchers at the Department of Connective Tissue Research use hyaluronic acid and cortisone injections as part of their case study (Ref 1) (Ref 2). This case study was to investigate cortisone injections used by themselves alone and with a cortisone injection and hyaluronic acid combined. This experiment involved twelve racehorses suffering from traumatic and degenerative arthritis between the ages of 3 and 10. The horses were grouped depending on the severity of their condition. According to the findings of this experiment, the horses treated with cortisone and hyaluronic acid showed excellent improvement compared to cortisone injection alone. A further study showed that hyaluronic acid injections achieved the same result when used alone for horses with traumatic arthritis. Due to the stress on the horses' joints during racing, racehorses may develop traumatic arthritis in the carpal, tarsal, fetlock, and coffin joints.

This case study (Ref 3) was to determine the effects of oral hyaluronic acid. Fifty-five dogs with Tibial Tuberosity advancement surgery and had been diagnosed with Cranial Cruciate ligament injury were administered oral hyaluronic acid. There were two groups of dogs: Group A(placebo) and Group B(HA). A ten-week follow-up was performed before and after surgery to measure the results. A significant finding supports that oral Hyaluronic acid administration to help manage osteoarthritis in dogs may be beneficial.

Veterinary practitioners have used hyaluronic acid for a decade to treat osteoarthritis in animals through injections. There is a disadvantage to intravenous injection of hyaluronic acid in that a professional is required. In addition, there is the possibility of infection at the injection site, and it is costly. Oral administration of hyaluronic acid provides a balanced level throughout the body, is easy to administer, and has no cost vet fees. It has been determined that daily consumption of oral hyaluronic acid can alleviate joint pain. Research has shown animals such as horses and dogs absorb it better when taken orally rather than injected.

Glucosamine is a well-studied joint support supplement. The body naturally produces this amino molecule.

The glucosamine compound is located in cartilage, the tough tissue that cushions joints. In addition to being one of the fundamental building blockers of cartilage, it also helps to protect the ends of bones, allowing them to move smoothly together. As the body ages, its natural production declines, but in supplement form, it can help support joints.

The use of glucosamine in this situation may be beneficial. In addition to balancing collagen and protecting proteoglycan synthesis in the cartilage, it scavenges free radicals and may have a mild anti-inflammatory effect.

A review of scientific studies has shown that taking glucosamine can relieve symptoms of osteoarthritis pain caused by inflammation, breaks, and eventual cartilage loss.